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Job-ID
23/02
Application by 28.02.2023

The Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) in Jena is a federal and state government-funded research institute and member of the Leibniz Association (Leibniz-Gemeinschaft). FLI’ s internationally visible and highly competitive research is focused on understanding the mechanisms of aging and associated age-related diseases. Scientists from over 40 countries are currently investigating the molecular mechanisms of aging and the occurrence of age-related diseases. Our aim is to create the basis for new approaches in medicine as a way to improve the health of the elderly (www.leibniz-fli.de).

The research group “Nerve Regeneration” led by Prof. Dr. Helen Morrison at the Leibniz Institute on Aging – Fritz Lipmann Institute is looking for a Postdoctoral Scientist:

Postdoc (m/f/d)
Tumor Biology

Research focus of the Lab:
The Morrison lab is interested in the processes of peripheral nerve regeneration, the nature of cell communication, and the mis-wiring of signalling pathways in disease and the aging process. We focus on age-dependent impairments underlying nervous system maintenance and regeneration, as well as on disease mechanisms for disorders of myelinating cells and nervous system tumors. Our aim is to perform translational work in each of these areas to facilitate the development of new therapeutic avenues.

The current position is part of a new collaborative pre-clinical project financed by the Children’s Tumor Foundation (CTF) until end of 2025. The overall focus of the project is the development of a therapeutic gene editing approach to causally treat Neurofibromatosis Type II (NF2) disease. Therapy development follows a well-defined step-by-step milestone approach together with external partners.

Tasks and Challenges:

We are looking for a highly motivated postdoctoral scientist to join our pre-clinical project team. Successful applicants will be enthusiastic about translating fundamental research towards novel therapeutic approaches to treat peripheral nerve pathologies, in particular Neurofibromatosis Type II (NF2). While embedded in an established, collaborative team, the successful applicant will show a high level of proactive independence, actively driving project development and execution as well as contributing to further expanding our pre-clinical expertise.

The postdoctoral scientist will employ a broad spectrum of techniques ranging from molecular biology and imaging techniques to mammalian cell culture and ex vivo as well as in vivo mouse work, including therapeutic injections and peripheral nerve surgery. Where applicable, the postdoctoral scientist will perform this work within our established project framework following human clinical trial and reporting standards.

        Requirements:

        • PhD in Biology or related field
        • Experience in mammalian cell culture
        • Experience in molecular biology techniques (e.g. western blot, PCR, RT-qPCR, ICC, IHC)
        • Willingness to work with laboratory mice
        • Meticulous work attitude and keen eyes for details
        • Inclination towards rigorous, comprehensive documentation and dissemination of (pre-clinical) research data

          will be a plus:
        • FELASA B certification or equivalent
        • Prior experience in working with laboratory mice, particularly surgery and i.v. injections
        • Prior experience in biosafety level 2 work (viral transductions)
            1. Experience in cellular assays (e.g. EdU incorporation, soft agar colony formation)

            We offer:

            • A position in a well-equipped and motivated lab that aims to bridge bench and clinical research.
            • Access to multiple state-of-the-art facilities. Our work is embedded in the Beutenberg Campus, an interdisciplinary base for innovative research.
            • A position integrated in the FLI PostDoc Network. The Network promotes interdisciplinary collaborations involving clinician scientists, basic scientists and bioinformaticians and supports career development and postdoctoral training courses.
            • The contract conditions and the salary will be according to the collective labour agreement for public service employees of the federal states of Germany (TV-L E13) with a contract according the project duration.
            • Flexible working time, a family friendly working environment including support for child care solutions and dual career.

            Application:

            Please apply online through the FLI application portal by 28.02.2023.





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